Frailty is independently associated with worse outcomes and increased resource utilization following endometrial cancer surgery
| Autor: | Morcos Nakhla, Cortney M Eakin, Ava Mandelbaum, Beth Karlan, Peyman Benharash, Ritu Salani, Joshua G Cohen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of Gynecologic Cancer. 32:1135-1140 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1136/ijgc-2022-003484 |
| Popis: | ObjectiveFrailty has been associated with poorer surgical outcomes and is a critical factor in procedural risk assessment. The objective of this study is to assess the impact of frailty on surgical outcomes in patients with endometrial cancer.MethodsPatients undergoing inpatient gynecologic surgery for endometrial cancer were identified using the 2005–2017 Nationwide Inpatient Sample database. The Johns Hopkins Adjusted Clinical Groups frailty-defining diagnosis indicator was used to designate frailty. Multivariate regression models were used to assess the association of frailty with postoperative outcomes and resource use.ResultsOf 339 846 patients, 2.9% (9868) were considered frail. After adjusting for patient and hospital characteristics, frailty was associated with a four-fold increase in inpatient mortality (adjusted OR (aOR) 4.1; pConclusionsFrailty is independently associated with worse surgical outcomes, including increased mortality and resource use, in women undergoing surgery for endometrial cancer. Though in recent years there have been improvements in mortality in the frail population, further efforts to mitigate the impact of frailty should be explored. |
| Databáze: | OpenAIRE |
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