COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy
Autor: | Anderson F. Brito, Nathan D. Grubaugh, Juergen K. V. Reichardt, Vito Luigi Colona, Michela Biancolella, Giuseppe Novelli, Ruty Mehrian-Shai, Lucio Luzzatto, Vasilis Vasiliou |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19) Genomics Population health Review QH426-470 03 medical and health sciences Politics 0302 clinical medicine Political science Drug Discovery Pandemic Milestone (project management) Genetics Humans Genetic Predisposition to Disease 030212 general & internal medicine Molecular Biology Pandemics Health policy 030304 developmental biology 0303 health sciences Vaccines Synthetic Vaccines Population Health business.industry SARS-CoV-2 Health Policy Variants Antibodies Monoclonal COVID-19 Public relations Vaccination Coronavirus Settore MED/03 Molecular Medicine Medicine Monoclonal antibodies business |
Zdroj: | Human Genomics, Vol 15, Iss 1, Pp 1-13 (2021) Human Genomics |
ISSN: | 1479-7364 |
Popis: | COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents. Supplementary Information The online version contains supplementary material available at 10.1186/s40246-021-00326-3. |
Databáze: | OpenAIRE |
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