Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
| Autor: | Zafer Asım Kaplancıklı, Şafak Ulusoylar Yıldırım, Mehlika Dilek Altıntop, Gülşen Akalın Çiftçi |
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| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Çiftçi, Gülsen Akalın, Altıntop, Mehlika Dilek, Kaplancıklı, Zafer Asım |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Popis: | WOS: 000336742500010 Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung adenocarcinoma (A549) and rat glioma (C6) cell lines. The cytotoxicity of the compounds on both cell lines was determined, and the effects of these compounds on DNA synthesis were measured. Compounds 2 and 6 which exhibited significant cytotoxic activity in MTT assay were chosen for flow cytometric analyses to determine apoptotic percent of cells. These compounds also exhibited better DNA synthesis inhibition activity on cancer cells. Compound 6 carrying 2,4-dichlorophenyl substituent exhibited the highest apoptotic effect on A549 cells via the induction of Caspase 3 activity. It was suggested that compounds 2 and 6 can be identified as the most promising anticancer agents against A549 and C6 cancer cell lines. |
| Databáze: | OpenAIRE |
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