Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics

Autor: Wafa Skalli, Pierre-Yves Rohan, Stéphane Bordas, Stéphane Urcun, Giuseppe Sciumè, Pierre Nassoy
Přispěvatelé: Institut de Biomecanique Humaine Georges Charpak, Arts et Métiers ParisTech-Université Paris 13 (UP13), Institut de Biomécanique Humaine Georges Charpak (IBHGC), Université Sorbonne Paris Nord-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Laboratoire Photonique, Numérique et Nanosciences (LP2N), Université Sciences et Technologies - Bordeaux 1-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS), University of Luxembourg [Luxembourg], Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2021
Předmět:
0301 basic medicine
Interstitial Fluid
Physiology
Stiffness
0302 clinical medicine
Mathematical and Statistical Techniques
[MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph]
Neoplasms
Medicine and Health Sciences
Extraction Techniques
Multidisciplinary
Mathematical Models
Physics
Prostate Cancer
Prostate Diseases
Body Fluids
Extracellular Matrix
Chemistry
Oncology
Physical Sciences
Medicine
Anatomy
Crystal twinning
Biological system
Physical Laws and Principles
Porosity
Research Article
Chemical Elements
Materials science
Alginates
Science
Urology
Materials Science
Material Properties
[SDV.CAN]Life Sciences [q-bio]/Cancer
Research and Analysis Methods
03 medical and health sciences
Conservation of Mass
Interstitial fluid
Spheroids
Cellular
Mechanical Properties
Animals
Humans
Tumor growth
Solid-Phase Extraction
Sensitivity analyses
Mécanique: Biomécanique [Sciences de l'ingénieur]
Mechanical Phenomena
Perspective (graphical)
Spheroid
Capsule
Cancers and Neoplasms
Biology and Life Sciences
Extracellular Fluid
Oxygen
Genitourinary Tract Tumors
030104 developmental biology
Porous medium
030217 neurology & neurosurgery
Zdroj: PLOS ONE
PLoS ONE
PLoS ONE, Public Library of Science, 2021, 16 (7), pp.e0254512. ⟨10.1371/journal.pone.0254512⟩
PLoS ONE, Vol 16, Iss 7, p e0254512 (2021)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0254512
Popis: Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play. Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.
Databáze: OpenAIRE
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