Maternal Vaginal Colonization and Extended-Spectrum Beta-Lactamase-Producing Bacteria in Vietnamese Pregnant Women

Autor: Vu Van Du, Nguyen Van Tuan, Hoang Van Tong, Can Van Mao, Nghiem Duc Thuan, Dennis Nurjadi, Ho Anh Son, Nguyen Thanh Viet, Thirumalaisamy P. Velavan, Srinivas Reddy Pallerla, Nguyen Linh Toan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Klebsiella pneumoniae
medicine.medical_treatment
030106 microbiology
extended-spectrum beta-lactamase
carbapenem resistance
RM1-950
Biochemistry
Microbiology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Antibiotic resistance
Enterobacterales
medicine
Escherichia coli
polycyclic compounds
Pharmacology (medical)
Colonization
030212 general & internal medicine
antimicrobial resistance
General Pharmacology
Toxicology and Pharmaceutics
Risk factor
Pregnancy
biology
Obstetrics
business.industry
Gestational age
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Infectious Diseases
chemistry
Vietnam
Beta-lactamase
bacteria
Therapeutics. Pharmacology
MacConkey agar
business
pregnant women
Zdroj: Antibiotics
Volume 10
Issue 5
Antibiotics, Vol 10, Iss 572, p 572 (2021)
ISSN: 2079-6382
DOI: 10.3390/antibiotics10050572
Popis: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) resistance to commonly prescribed drugs is increasing in Vietnam. During pregnancy, ESBL-E may predispose women to reproductive tract infections and increases the risk for neonatal morbidity. Vaginal colonization and infections by Escherichia coli and Klebsiella pneumoniae are seldom studied in Vietnam. In this study, we investigated ESBL-producing Enterobacterales in the birth canal of pregnant women. Between 2016 and 2020, vaginal swabs were collected from 3104 pregnant women (mean gestational age of 31 weeks) and inoculated onto MacConkey agar plates. Colonies were subjected to direct identification and antimicrobial susceptibility testing using the VITEK®-2 automated compact system and disk diffusion. ESBL production was determined phenotypically. E. coli, Klebsiella species were identified in 30% (918/3104) of the vaginal swabs, with E. coli being the most common (73%
667/918). ESBL-production was detected in 47% (432/918) of Enterobacterales, with frequent multidrug-resistant phenotype. The overall prevalence of carbapenem resistance was low (8%). Over 20% of Klebsiella spp. were carbapenem-resistant. Pregnant women had a high prevalence of colonization and may transmit ESBL-E to neonates at birth, an important risk factor to be considered. The high rate of ESBL-producers and carbapenem resistance in Enterobacterales in Vietnam emphasizes the need for consequent surveillance and access to molecular typing.
Databáze: OpenAIRE
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