High-sensitivity C-reactive protein and parameters of left ventricular dysfunction
| Autor: | Joshua C. Vessey, Ivor L. Gerber, Gregory M. Marcus, Andrew D. Michaels, Michele Huddleston, Sanjiv J. Shah, Elyse Foster, Kanu Chatterjee, Barry H. McKeown, Mark V. Jordan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Heart Ventricles Ventricular Dysfunction Left Diastole Diabetes mellitus Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Ventricular Pressure Humans Prospective Studies Cardiac catheterization Aged Ejection fraction biology business.industry C-reactive protein Stroke Volume Middle Aged medicine.disease Preload C-Reactive Protein Cross-Sectional Studies Heart failure cardiovascular system biology.protein Ventricular pressure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiac failure. 12(1) |
| ISSN: | 1532-8414 |
| Popis: | Background Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP. Methods and Results In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus ( P =.006) and heart failure ( P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated ( P =.046). Conclusion CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect