ANCOVA approach for shelf life analysis of stability study of multiple factor designs

Autor:	Wen-Jen Chen, Yi Tsong, Chi Wan Chen
Rok vydání:	2003
Předmět:	Pharmacology Statistics and Probability Analysis of covariance Models Statistical Time Factors Total sum of squares Generalization Model selection Drug Storage Pooling Explained sum of squares Residual sum of squares Drug Stability Linear regression Statistics Multivariate Analysis Pharmacology (medical) Mathematics
Zdroj:	Journal of biopharmaceutical statistics. 13(3)
ISSN:	1054-3406
Popis:	For a traditional multiple batch stability design with no other factor, the conventional analysis is analysis of covariance (ANCOVA) modeling using F-tests based on type I sum of squares to determine whether the batches may be pooled for a common estimate of the linear regression line(s). In the last decade, many multiple factor designs were proposed in stability studies. With the objective of model selection, the generalization of the conventional ANCOVA model using type I sum of squares to designs with multiple factors requires a prespecified hierarchical pooling test ordering to determine whether any of the factors may be eliminated. Different shelf life estimates may be derived using different hierarchical pooling test orderings. On the other hand, setting the hierarchical ordering can be subjective and controversial. The stepwise modeling based on F-tests using type III sum of squares for model determination and factor elimination is proposed to eliminate such difficulties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5491b6aaa14a12526aed0fb3d08b10 https://pubmed.ncbi.nlm.nih.gov/12921388 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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