Chemopreventive Effects of 4-Methylthio-3-butenyl Isothiocyanate (Raphasatin) but Not Curcumin against Pancreatic Carcinogenesis in Hamsters
| Autor: | Takashi Umemura, Kumiko Ogawa, Tomoki Inoue, Toshiya Okamura, Shigehisa Okamoto, Masako Tasaki, Yasushi Nakamura, Eun Young Park, Akiyoshi Nishikawa, Yuji Ishii, Tomoaki Matsuo, Kenji Sato |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Curcumin Nitrosamines Hamster Adenocarcinoma chemistry.chemical_compound Isothiocyanates Cricetinae Internal medicine Pancreatic cancer medicine Animals Anticarcinogenic Agents Pancreas Hyperplasia Mesocricetus biology 4-methylthio-3-butenyl isothiocyanate General Chemistry biology.organism_classification medicine.disease Diet Pancreatic Neoplasms Endocrinology chemistry Isothiocyanate Carcinogens Pancreatic carcinogenesis General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 61:2103-2108 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf3003174 |
| Popis: | The modifying effects of 4-methylthio-3-butenyl isothiocyanate (MTBITC) and curcumin were investigated in N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamsters. Male 6-week-old Syrian hamsters were subcutaneously injected with 10 mg/kg body weight (b.w.) of BOP four times a week, and fed a diet supplemented with 80 mg/kg diet of MTBITC, equivalent to 4.6 mg/kg b.w./day for the initiation stage or 3.8 mg/kg b.w./day for the postinitiation stage administration, respectively, or 2000 mg/kg diet of curcumin, equivalent to 118.8 mg/kg b.w./day for the initiation stage or 100.8 mg/kg b.w./day for the postinitiation stage administration, respectively. The incidence of combined pancreatic lesions, including atypical hyperplasias and adenocarcinomas, was significantly decreased to 55% (P < 0.05) by the 80 mg/kg diet MTBITC given during the initiation stage as compared to the BOP alone group (85%) but not by the curcumin administration at 16 weeks after the BOP-treatment. In the second study, the multiplicity of combined pancreatic lesions was also significantly decreased to 0.50 ± 0.51 (P < 0.05) by 700 mg/kg diet MTBITC given in the initiation stage (equivalent to 59.0 mg/kg b.w./day) as compared to the BOP alone group (1.10 ± 1.02). Our results indicate that the naturally occurring isothiocyanate MTBITC may exert preventive effects against BOP-initiation of hamster pancreatic carcinogenesis. |
| Databáze: | OpenAIRE |
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