Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry
| Autor: | Denisa Rozsivalova, Jana Alahakoon, Juraj Kultan, Andrea Mullerova, Kristián Brat, Daniel Krejci, Ondrej Venclicek, Libor Havel, Martin Svaton, Martina Vasakova, Petra Smickova, Ondrej Fischer, Kristyna Hrda, Jana Skrickova, Zsuzsanna Gyorfy, Miloslav Marel, Gabriela Krakorova, P. Opálka, Michal Hrnčiarik, Jaroslav Duba, Jiri Silar, Michal Svoboda, Michal Jirousek, Petr Zuna, J. Krejčí, Lydia Zarnayova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Czech Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors Population Disease Young Adult 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor medicine Humans Prospective Studies Registries Radical surgery Stage (cooking) Pneumonectomy Lung cancer education Survival rate Aged Czech Republic Neoplasm Staging Aged 80 and over education.field_of_study Smokers business.industry Non-Smokers General Medicine Middle Aged medicine.disease Small Cell Lung Carcinoma language.human_language respiratory tract diseases 3. Good health Treatment Outcome Oncology 030220 oncology & carcinogenesis Mutation language Adenocarcinoma Female Ex-Smokers business |
| Zdroj: | Anticancer Research. 41:5549-5556 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15368 |
| Popis: | Background/aim LUCAS is a clinical lung cancer registry (ClinicalTrials.gov identifier is NCT04228237), prospectively collecting data from newly diagnosed lung cancer patients in seven pneumooncology centers in the Czech Republic, since June 1, 2018. The aim of the study was to assess the stage of the disease at the time of diagnosis, percentage of morphological types, survival, percentage of driving mutations, eligibility for radical surgery, and percentage of patients who undergo radical surgery, in the non-smoking population in comparison with smokers and former smokers. Patients and methods The total number of patients in the registry at the time of the analysis was 2,743. Only 2,439 patients with complete records (smoking status, stage, and type of tumor) were included in this study. Results The analysis indicated that non-smokers are diagnosed at a later stage of the disease but they have a better survival rate than smokers. Fewer smokers with stage III disease who are eligible for radical surgery will undergo surgery compared to non-smokers with the same clinical stage. Driving mutations are more common in non-smokers, even after adjustment for the more frequent occurrence of adenocarcinoma in the group of non-smokers. Conclusion The data from LUCAS registry are consistent with already known facts, suggesting that the LUCAS registry is a useful clinical tool. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|