Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice
Autor: | Eduardo A.V. Marinho, Renan Santos-Baldaia, Thaísa Barros-Santos, A.W. Hollais, Matheus Libarino-Santos, Roberto Frussa-Filho, Ana Catherine Gomes de Santana Santos, Aurea Lorena Nunes Borges, M.A. Baldaia, Nina Rosa Nunes Brandão, Elisangela G. Cata-Preta, Laís F. Berro, Alexandre J. Oliveira-Lima |
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Rok vydání: | 2019 |
Předmět: |
Agonist
Alcohol Drinking medicine.drug_class Conditioning Classical Aripiprazole Alcohol use disorder Pharmacology Environment Toxicology 03 medical and health sciences Mice 0302 clinical medicine Dopamine receptor D2 medicine Animals Pharmacology (medical) 030212 general & internal medicine Behavior Animal Ethanol business.industry Therapeutic effect Receptor antagonist medicine.disease Conditioned place preference Psychiatry and Mental health Disease Models Animal Dopamine Agonists Female Serotonin business Alcohol-Related Disorders 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Drug and alcohol dependence. 208 |
ISSN: | 1879-0046 |
Popis: | Background Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization in a context-dependent manner, suggesting that the treatment environment may modulate the therapeutic effects of aripiprazole. The present study aimed to evaluate the effects of treatment with aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice, and the role of the treatment environment in those effects. Methods Adult female mice were either sensitized with ethanol injections in the open-field apparatus, or conditioned with ethanol in the conditioned place preference (CPP) apparatus. Animals were then treated with vehicle or 0.1 mg/kg aripiprazole paired to the test environment (open-field or CPP apparatus) or not (home-cage treatments) for 4 alternate days, and the subsequent expression of behavioral sensitization or CPP to ethanol was evaluated during or following an ethanol re-exposure, respectively. Results Repeated treatment with aripiprazole attenuated the expression of ethanol-induced behavioral sensitization regardless of the treatment environment. Treatment with aripiprazole was only effective at preventing the reinstatement of ethanol-induced CPP when paired with the ethanol-associated environment, but not when administered in the home-cage. Conclusions The present findings corroborate previous studies suggesting the effectiveness of aripiprazole for the treatment of alcohol use disorder. Our results also point to an important role of the treatment environment in the therapeutic effects of aripiprazole in rodent models of ethanol abuse. |
Databáze: | OpenAIRE |
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