Skin carcinomas and micronucleus induction in epidermal keratinocytes following 12-O-tetradecanoylphorbol-13-acetate and mezerein treatment
| Autor: | Hartmut H. Steinel, A.M. Bonin, Robert S.U. Baker, K. Meher-Homji |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Keratinocytes
Mezerein Skin Neoplasms Ratón Health Toxicology and Mutagenesis Biology Toxicology 12-O-Tetradecanoylphorbol-13-acetate Mice chemistry.chemical_compound Genetics medicine Animals Genetics (clinical) Micronucleus Tests integumentary system Epidermis (botany) Terpenes Molecular biology Kinetics medicine.anatomical_structure chemistry Tetradecanoylphorbol Acetate Micronucleus test Immunology Carcinogens Female Diterpenes Keratinocyte Micronucleus |
| Zdroj: | Mutagenesis. 7:199-203 |
| ISSN: | 1464-3804 0267-8357 |
| DOI: | 10.1093/mutage/7.3.199 |
| Popis: | Phorbol esters are chemical compounds which have the ability to promote carcinogenesis in the skin of mice. In the HRA/Skh mouse strain, an initiation-promotion assay substantiated evidence that mezerein acts as a complete promoter. Complete promotion with 9.0 nmol mezerein induced a total of 53 papillomas in 28 mice within 40 weeks, while 1.5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA), using the same application regime, resulted in a total of 298 papillomas in 58 mice. However, 7.6% of the papillomas in the mezerein group progressed to carcinomas, compared with 0.7% in the TPA group. Approximately the same molar concentrations of TPA and mezerein induced a dose-dependent and reproducible increase in micronuclei in supra-basal cells derived from the epidermis of treated mice. In contrast, the latter compound was less toxic to these cells and induced higher numbers of micronuclei at the higher concentrations. |
| Databáze: | OpenAIRE |
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