Mobilization of Hematopoietic Stem Cells into Peripheral Blood for Autologous Transplantation Seems Less Efficacious in Poor Mobilizers with the Use of a Biosimilar of Filgrastim and Plerixafor: A Retrospective Comparative Analysis
| Autor: | Parody Porras, Rocío, Sánchez Ortega, Isabel, Ferrá, Christelle, Guardia, Ramon, Talarn, Carme, Encuentra, Maite, Fort, Eduard, López, David, Morgades, Mireia, Alonso, Eva, Ortega, Sandra, Sarrá, Josep, Gallardo, David, Ribera, Josep M., Sureda, Anna, Universitat Autònoma de Barcelona |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.drug_class Pharmaceutical biotechnology Stem cells Filgrastim Neutropenia Immunostimulant Internal medicine Medicine Autologous transplantation RC254-282 Biosimilars Mobilization business.industry Brief Report Plerixafor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Combination chemotherapy medicine.disease Stem cell mobilization Stem cell business Cèl·lules mare Biotecnologia farmacèutica medicine.drug |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Oncology and Therapy Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Oncology and Therapy, Vol 8, Iss 2, Pp 311-324 (2020) |
| Popis: | Introduction Biosimilars of granulocyte colony-stimulating factors (G-CSF) have shown similar efficacy to originator filgrastim (Neupogen® [NEU]; Amgen Inc.) as prophylaxis in neutropenia and in the mobilization of stem cells in patients receiving combination chemotherapy with G-CSF. Methods This was a retrospective study in which the characteristics of stem cell mobilization treated with a G-CSF alone were compared in 216 patients and 56 donors. The two G-CSF compared were NEU and the biosimilar filgrastim Zarzio® (Sandoz GmbH) (referred to hereafter as BIO). Primary objectives were mobilization rate (minimum of 10 × 103/ml CD34+ on day 4 of treatment [day +4]) and use of the immunostimulant plerixafor (PLEX) in each group. Results The general characteristics of the patients receiving NEU (n = 138) and those receiving BIO (n = 78) did not differ significantly. PLEX was used in 24% of BIO patients and in 25.7% of NEU patients. The median CD34+ cell count on day +4 was significantly lower in BIO patients who needed PLEX than in those who did not (2.4 vs. 4.8 × 103/ml; p = 0.002), as was the final CD34+ cell count (2.5 vs. 3.3 × 106/kg; p 0.03). Mobilization failure rate was higher in the BIO group than in the NEU group (20 vs. 0%; p = 0.01). With respect to donors, more than one apheresis was needed in three BIO donors, one of them with PLEX. The use of BIO was the only risk factor for mobilization failure in patients who needed PLEX (hazard ratio 10.3; 95% confidence interval 1.3–77.8). Conclusion The study revealed that BIO had a lower efficacy for stem cell mobilization when the only treatment was G-CSF, especially in poor mobilizers needing PLEX. |
| Databáze: | OpenAIRE |
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