A five-membered lactone prodrug of CBI-based analogs of the duocarmycins

Autor:	Mika Uematsu, Daniel M. Brody, Dale L. Boger
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Stereochemistry Reagent Organic Chemistry Drug Discovery Prodrug Biochemistry Duocarmycin Lactone Article
Zdroj:	Tetrahedron letters. 56(23)
ISSN:	0040-4039
Popis:	The preparation, characterization, and examination of the CBI-based 5-membered lactone 5 capable of serving as a prodrug or protein (antibody) conjugation reagent are disclosed along with its incorporation into the corresponding CC-1065 and duocarmycin analog 6, and the establishment of their properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed65cd385ece0dfcac3f29c2e67b057 https://pubmed.ncbi.nlm.nih.gov/26069351 Zobrazit plný text záznamu Full Text from ScienceDirect