International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
| Autor: | Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, Palumbo A, Jagannath S, Blade J, Lonial S, Dimopoulos M, Comenzo R, Einsele H, Barlogie B, Anderson K, Gertz M, Harousseau JL, Attal M, Sonneveld P, Boccadoro M, Morgan G, Richardson P, Sezer O, Mateos MV, Joshua D, Turesson I, Chen W, Shimizu K, Powles R, Rajkumar SV, Durie BG, International Myeloma Working Group, TOSI, PATRIZIA, CAVO, MICHELE |
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| Přispěvatelé: | Faculty of Economic and Social Sciences and Solvay Business School, Radiology & Nuclear Medicine, Hematology, Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, Palumbo A, Jagannath S, Blade J, Lonial S, Dimopoulos M, Comenzo R, Einsele H, Barlogie B, Anderson K, Gertz M, Harousseau JL, Attal M, Tosi P, Sonneveld P, Boccadoro M, Morgan G, Richardson P, Sezer O, Mateos MV, Cavo M, Joshua D, Turesson I, Chen W, Shimizu K, Powles R, Rajkumar SV, Durie BG, International Myeloma Working Group. |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
030204 cardiovascular system & hematology Plasma cell GUIDELINES 0302 clinical medicine MULTIPLE MYELOMA hemic and lymphatic diseases serum immunoglobulin-free light chain Multiple myeloma Hematology biology medicine.diagnostic_test Disease Management Amyloidosis PCD Prognosis 3. Good health FLC medicine.anatomical_structure 030220 oncology & carcinogenesis Serum protein electrophoresis oncology Immunofixation medicine.medical_specialty Immunoglobulin lambda-Chains/analysis Context (language use) Immunoglobulin light chain Amyloidosis/diagnosis Immunoglobulin Light Chains/analysis methods Immunoglobulin kappa-Chains 03 medical and health sciences Immunoglobulin lambda-Chains Internal medicine medicine Humans Multiple Myeloma/diagnosis Neoplasms Plasma Cell business.industry Immunoglobulin kappa-Chains/analysis medicine.disease consensus guidelines Immunology biology.protein plasma cell disorder Immunoglobulin Light Chains Bone marrow Neoplasms Plasma Cell/diagnosis business |
| Zdroj: | Leukemia, 23(2), 215-224. Nature Publishing Group |
| ISSN: | 0887-6924 |
| Popis: | The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields high sensitivity, and negates the need for 24-h urine studies for diagnoses other than light chain amyloidosis (AL). Second, the baseline FLC measurement is of major prognostic value in virtually every PCD. Third, the FLC assay allows for quantitative monitoring of patients with oligosecretory PCD, including AL, oligosecretory myeloma and nearly two-thirds of patients who had previously been deemed to have non-secretory myeloma. In AL patients, serial FLC measurements outperform PEL and immunofixation. In oligosecretory myeloma patients, although not formally validated, serial FLC measurements reduce the need for frequent bone marrow biopsies. In contrast, there are no data to support using FLC assay in place of 24-h urine PEL for monitoring or for serial measurements in PCD with measurable disease by serum or urine PEL. This paper provides consensus guidelines for the use of this important assay, in the diagnosis and management of clonal PCD. |
| Databáze: | OpenAIRE |
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