Synthesis, characterization and pharmacological evaluation of (Z)-2-(5-(biphenyl-4-yl)-3-(1-(imino)ethyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)phenol derivatives as potent antimicrobial and antioxidant agents
| Autor: | Prabodh Chander Sharma, Dipan Malhotra, Ravindra K. Rawal, Richa Dhingra, Manav Malhotra, Aakash Deep |
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| Jazyk: | angličtina |
| Předmět: |
Antioxidant
Chemistry(all) Stereochemistry General Chemical Engineering medicine.medical_treatment Oxadiazole Antifungal 030226 pharmacology & pharmacy 01 natural sciences lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antioxidant activity Biological assays Lipophilicity medicine Moiety Candida albicans GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) ComputingMilieux_MISCELLANEOUS biology 010405 organic chemistry Aspergillus niger General Chemistry Antimicrobial biology.organism_classification 0104 chemical sciences Antibacterial lcsh:QD1-999 chemistry Chemical Engineering(all) Schiff bases Pharmacophore 1 3 4-Oxadiazoles |
| Zdroj: | Arabian Journal of Chemistry, Vol 10, Iss S1, Pp S1022-S1031 (2017) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2013.01.005 |
| Popis: | The oxadiazole pharmacophore is considered a viable lead structure for the synthesis of more efficacious and broad spectrum antimicrobial agents. The significance of this study was to prepare various oxadiazole derivatives by introducing the 1,3,4 oxadiazole core into several molecules to explore the possibilities of some altered biological activities. Therefore, the study presents the synthesis, antimicrobial and antioxidant evaluation of a series of 1,3,4 substituted oxadiazole derivatives. Antimicrobial evaluation revealed that eighteen compounds were able to display variable growth inhibitory effects on the tested Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus , Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli and fungal strains Candida albicans and Aspergillus niger . Among the synthesized derivative analogues 6f , 6l and 6r were found to be the most effective antibacterial agents. While the compounds 6c , 6l and 6q were found to be the most promising antifungal agents. On the other hand, all the synthesized compounds 6a–6r were subjected to antioxidant activity but only analogues 6l and 6q were found to exhibit potent antioxidant activity. Further compound 6l containing p -nitro phenyl moiety along with oxadiazole pharmacophore proved to be the most active antimicrobial and antioxidant agent. |
| Databáze: | OpenAIRE |
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