Synthesis of several chemotactic peptide antagonists
| Autor: | Natesa Muthukumaraswamy, Delia Pinon, Alan R. Day, Richard J. Freer |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Chemotactic peptide
Dipeptide N-Formylmethionine biology Physiology Chemistry Stereochemistry Neutrophils Chemotaxis In Vitro Techniques biology.organism_classification Biochemistry N-Formylmethionine Leucyl-Phenylalanine Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Methionine Tetra Animals Rabbits Oligopeptides Glucuronidase |
| Zdroj: | Peptides. 1(4) |
| ISSN: | 0196-9781 |
| Popis: | The following peptides have been synthesized using classical mixed anhydride methods: Boc-Leu-Phe-OH, Boc-Phe-Leu-Phe-OH, Boc-Leu-Phe-Leu-Phe-OH and Boc-Phe-Leu-Phe-Leu-Phe-OH. The tri, tetra and pentapeptides inhibit Formyl-Met-Leu-Phe-OH induced release of β-glucuronidase from rabbit peritoneal neutrophils. The antagonists exhibit ID50 concentrations in the range 2.6−5.7×10−7M. The dipeptide was inactive at all concentrations tested. |
| Databáze: | OpenAIRE |
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