Exposure to metals premixed with microplastics increases toxicity through bioconcentration and impairs antioxidant defense and cholinergic response in a marine mysid
| Autor: | Md. Niamul Haque, Hye-Jin Eom, Jae-Sung Rhee, Somyeong Lee |
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| Rok vydání: | 2021 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Microplastics Antioxidant Physiology Health Toxicology and Mutagenesis medicine.medical_treatment Bioconcentration Metal toxicity Pharmacology Toxicology Ecotoxicology Biochemistry Antioxidants Arthropod Proteins Lethal Dose 50 chemistry.chemical_compound Crustacea Malondialdehyde medicine Toxicity Tests Acute Animals skin and connective tissue diseases biology Environmental Biomarkers Chemistry Neurotoxicity nutritional and metabolic diseases Cell Biology General Medicine Glutathione medicine.disease Enzymes Oxidative Stress Catalase Metals Toxicity biology.protein Acetylcholinesterase Water Pollutants Chemical |
| Zdroj: | Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 249 |
| ISSN: | 1532-0456 |
| Popis: | Coexistence of metals and microplastics (MPs) in aquatic environments represents a growing concern; however, little is known regarding the risks associated with their combined effects. Here, the effects of five metals (As, Cd, Cu, Pb, and Zn), alone or combined with MPs for various premixing durations (30 and 60 days), on the juvenile and adult stages of the marine mysid Neomysis awatschensis were evaluated. The toxicity (50% lethal concentration for 96 h) and bioconcentration of metals premixed with MPs were measured, and their effects on the antioxidant defense and cholinergic systems were examined. Metal toxicity increased with increasing premixing period with MPs, and juveniles were more sensitive to exposure to metals premixed with MPs than adults. Metal bioconcentration in the mysid body increased following co-exposure with MPs. Metals premixed with MPs significantly increased intracellular malondialdehyde content at both stages but decreased glutathione content in juveniles. At both stages, catalase and superoxide dismutase activity was suppressed following co-exposure to metals and MPs, except under the Cu treatment. Moreover, co-exposure inhibited acetylcholinesterase activity at both stages, suggesting cholinergic impairment. Taken together, metals and MPs produce synergistic detrimental effects on marine mysids in a stage-specific manner. Further studies are warranted to elucidate the role of MPs as a vector for contaminants and stimulator of toxicity in aquatic organisms. |
| Databáze: | OpenAIRE |
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