Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins
| Autor: | Prunet, A., Lefort, S., Delanoë-Ayari, H., Laperrousaz, B., Simon, G., Barentin, C., Saci, S., Argoul, F., Rieu, J.-P., Gobert, S., Rivière, C., Jung, Nora, Maguer-Satta, V., Guyot, Boris |
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| Přispěvatelé: | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon], maguer-satta, veronique |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research [SDV]Life Sciences [q-bio] Mammary gland Estrogen receptor [SDV.CAN]Life Sciences [q-bio]/Cancer Review [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain Biology Bone morphogenetic protein lcsh:RC254-282 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer [SDV.CAN] Life Sciences [q-bio]/Cancer bisphenol medicine Endocrine system ComputingMilieux_MISCELLANEOUS Progenitor [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology bone morphogenetic protein (BMP) Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease microenvironment 3. Good health [SDV] Life Sciences [q-bio] [SDV.TOX] Life Sciences [q-bio]/Toxicology 030104 developmental biology medicine.anatomical_structure [SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chain Oncology [SDV.TOX]Life Sciences [q-bio]/Toxicology 030220 oncology & carcinogenesis Cancer research Stem cell [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology hormones hormone substitutes and hormone antagonists epithelial stem cells estrogens |
| Zdroj: | Cancers Cancers, MDPI, 2019, 11 (9), pp.1351. ⟨10.3390/cancers11091351⟩ Cancers, Vol 11, Iss 9, p 1351 (2019) Cancers, 2019, 11 (9), pp.1351. ⟨10.3390/cancers11091351⟩ |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11091351⟩ |
| Popis: | International audience; Estrogens are major regulators of the mammary gland development, notably during puberty, via estrogen receptor (ER) activation, leading to the proliferation and differentiation of mammary cells. In addition to estrogens, the bone morphogenetic proteins (BMPs) family is involved in breast stem cell/progenitor commitment. However, these two pathways that synergistically contribute to the biology of the normal mammary gland have also been described to initiate and/or promote breast cancer development. In addition to intrinsic events, lifestyle habits and exposure to environmental cues are key risk factors for cancer in general, and especially for breast cancer. In the latter case, bisphenol A (BPA), an estrogen-mimetic compound, is a critical pollutant both in terms of the quantities released in our environment and of its known and speculated effects on mammary gland biology. In this review, we summarize the current knowledge on the actions of BMPs and estrogens in both normal mammary gland development and breast cancer initiation, dissemination, and resistance to treatment, focusing on the dysregulations of these processes by BPA but also by other bisphenols, including BPS and BPF, initially considered as safer alternatives to BPA. |
| Databáze: | OpenAIRE |
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