Excess Casein in the Diet Is Not the Unique Cause of Low-Grade Metabolic Acidosis: Role of a Deficit in Potassium Citrate in a Rat Model
| Autor: | Catherine Besson, Christian Rémésy, Christian Demigné, J. C. Tressol, Houda Sabboh |
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| Přispěvatelé: | Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Nitrogen Sodium Potassium PROTEIN Medicine (miscellaneous) chemistry.chemical_element Urine Urinalysis Biology Weight Gain CITRATE ACIDOSE METABOLIQUE LATENTE Excretion Eating Random Allocation chemistry.chemical_compound Potassium Citrate Internal medicine Casein medicine Animals Rats Wistar Acidosis Nutrition and Dietetics Dose-Response Relationship Drug METABOLIC ACIDOSIS LOW-GRADE Caseins Metabolic acidosis Hydrogen-Ion Concentration medicine.disease Rats Endocrinology chemistry Urea UREA medicine.symptom Energy Intake [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Annals of Nutrition and Metabolism Annals of Nutrition and Metabolism, Karger, 2006, 50 (3), pp.229-236. ⟨10.1159/000090901⟩ |
| ISSN: | 1421-9697 0250-6807 |
| DOI: | 10.1159/000090901 |
| Popis: | This study examined the effects of a dietary model of protein excess and K anion salt deficit on the occurrence of metabolic acidosis in rat. Rats were adapted to diets containing either 13 or 26% casein, together with mineral imbalance, through lowering K/increasing sodium/omitting alkalinizing anions. For each protein level, a group of rats was supplemented with K citrate. Dietary K citrate resulted in neutral urinary pH, whatever the protein level. Urea excretion was higher in rats adapted to 26% casein than 13% casein diets, but K citrate enhanced this excretion and suppressed ammonium elimination. No citraturia could be observed in acidotic rats, whereas K citrate greatly stimulated citraturia and 2-ketoglutarate excretion. In conclusion, low-grade metabolic acidosis can occur with a moderate protein level in the diet. K citrate was apparently less effective in rats adapted to the 26% casein level than in those adapted to the 13% casein level with regard to magnesium, citrate and 2-ketoglutarate concentrations in urine. |
| Databáze: | OpenAIRE |
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