Immunomodulatory Action of Levofloxacin on Cytokine Production by Human Peripheral Blood Mononuclear Cells
| Autor: | Chikako Kurita, Joji Kobayashi, Eiseki Usami, Toshiya Nakao, Shino Watanabe, Futoshi Yamazaki, Tomoaki Yoshimura, Hiroichi Nagai |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Interleukin 2
Ofloxacin medicine.medical_treatment Levofloxacin Biology Peripheral blood mononuclear cell Microbiology Adjuvants Immunologic Anti-Infective Agents Drug Discovery medicine Humans Pharmacology (medical) Receptor Cells Cultured Antibacterial agent Pharmacology Tumor Necrosis Factor-alpha Interleukin-8 Granulocyte-Macrophage Colony-Stimulating Factor General Medicine In vitro Infectious Diseases Cytokine Oncology Leukocytes Mononuclear Cytokines Interleukin-2 Tumor necrosis factor alpha Cell Division Interleukin-1 medicine.drug |
| Zdroj: | Chemotherapy. 42:459-464 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000239480 |
| Popis: | Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 micrograms/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by PHA-stimulated PBMC was suppressed at high concentrations of LVFX. Interleukin-1 beta production by lipopolysaccharide-stimulated PBMC was suppressed in a concentration-dependent manner by LVFX, and tumor necrosis factor-alpha production was suppressed at only the highest concentration. In contrast, interleukin-8 production was little affected by LVFX. These results show that LVFX has an immunomodulatory action on cytokines production by PBMC independent of its antimicrobial activity. |
| Databáze: | OpenAIRE |
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