Microfabricated cantilevers for measurement of subcellular and molecular forces

Autor: Harold G. Craighead, Gerald H. Pollack, D.H. Lilienfeld, Mark E. Fauver, Dwayne L. Dunaway
Rok vydání: 1998
Předmět:
Zdroj: IEEE Transactions on Biomedical Engineering. 45:891-898
ISSN: 0018-9294
DOI: 10.1109/10.686797
Popis: We present two new microfabricated cantilever-beam force transducers. The transducers were fabricated from thin silicon-nitride films, and were used respectively to measure forces generated by two small-muscle preparations: the single myofibril, and the single actin filament in contact with a myosin-coated surface. A simple resonance method was developed to characterize the transducers. Because of the high reproducibility of lever dimensions and the consistency of the modulus of elasticity, few calibration measurements sufficed to characterize the stiffness of all the levers on a single wafer.
Databáze: OpenAIRE