Prognostic significance of β-catenin and topoisomerase IIα in de novo acute myeloid leukemia
| Autor: | Jen-Tsun Lin, Jyh-Pyng Gau, Chih-Cheng Chen, Chang-Hsien Lu, Wan-Hsia Lo, Chieh Lan, Kuan-Der Lee, Jacqueline Ming Liu, Yuan-Bin Yu, Jie-Yu You, Ching-Fen Yang |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Antimetabolites Antineoplastic Myeloid Comorbidity Biology Cohort Studies Antigens Neoplasm Risk Factors Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans beta Catenin Survival analysis Aged Retrospective Studies Aged 80 and over Topoisomerase Cytarabine Myeloid leukemia Hematology Middle Aged Prognosis medicine.disease Survival Analysis Neoplasm Proteins DNA-Binding Proteins Wnt Proteins Leukemia Myeloid Acute Leukemia Haematopoiesis DNA Topoisomerases Type II medicine.anatomical_structure Karyotyping Catenin Immunology Cancer research biology.protein Female medicine.drug |
| Zdroj: | American Journal of Hematology. 84:87-92 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.21334 |
| Popis: | The Wnt/beta-catenin signaling is important for controlling self-renewal of hematopoietic stem cells and its constitutive activation has recently been documented in a significant proportion of acute myeloid leukemia (AML) cases. Topoisomerase IIalpha (Topo IIalpha) is a marker of cell proliferation and a crucial target for anthracycline cytotoxicity, the mainstay of management employed in AML. We retrospectively investigated the prognostic roles of beta-catenin and topo IIalpha in a cohort of 59 patients with newly diagnosed AML by immunohistochemistry. Aberrant beta-catenin expression was demonstrated in 13 patients (22%), and it was more likely to occur in those with unfavorable karyotypes. Advanced age and poor performance status adversely influenced the achievement of complete remission, while neither aberrant beta-catenin expression nor enhanced topo IIalpha activity did. On multivariate survival analysis, four factors independently predicted a shortened overall survival: aberrant beta-catenin expression, high topo IIalpha activity, poor-risk cytogenetics, and presence of at least one comorbidity factor. Our results suggest that both beta-catenin and topo IIalpha independently predicted an adverse prognosis and might serve as new markers for risk stratification in AML patients. |
| Databáze: | OpenAIRE |
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