Peripheral blood E2F1 mRNA in depression and following electroconvulsive therapy
| Autor: | Karen M. Ryan, Erik Kolshus, Declan M. McLoughlin, Claire L. McGrory |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Senescence endocrine system medicine.medical_specialty Psychosis medicine.medical_treatment Gene Expression 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Internal medicine microRNA medicine Humans RNA Messenger Electroconvulsive Therapy Biological Psychiatry Depression (differential diagnoses) Whole blood Pharmacology Depressive Disorder business.industry Promoter Middle Aged medicine.disease 030227 psychiatry Affect Treatment Outcome Endocrinology Psychotic Disorders Apoptosis Female biological phenomena cell phenomena and immunity business Biomarkers E2F1 Transcription Factor |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 89:380-385 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2018.10.011 |
| Popis: | The E2F transcription factors are a group of proteins that bind to the promotor region of the adenovirus E2 gene. E2F1, the first family member to be cloned, is linked to functions including cell proliferation and apoptosis, DNA repair, cell senescence and metabolism. We recently performed a deep sequencing study of micro-RNA changes in whole blood following ECT. Two micro-RNAs (miR-126-3p and miR-106a-5p) were identified and gene targeting analysis identified E2F1 as a shared target of these miRNAs. To our knowledge, no studies have examined E2F1 mRNA levels in patients with depression. Peripheral blood E2F1 mRNA levels were therefore examined in patients with depression, compared to healthy controls, and the effects of a course of ECT on peripheral blood E2F1 mRNA was investigated. Depressed patient and healthy control groups were balanced on the basis of age and sex. E2F1 mRNA levels were significantly lower in depressed patients in comparison to controls (p = .009) but did not change with ECT. There was no relationship between baseline E2F1 levels and depression severity, response to treatment, presence of psychosis or polarity of depression. There were no significant correlations between E2F1 levels and mood scores based on the HAM-D24. These results indicate that reduced peripheral blood E2F1 mRNA could be a trait feature of depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect