Ocimum basilicum L. (Lamiaceae) leaves aqueous extract improve learning and memory in the monosodium glutamate-induced neurotoxicity model of Alzheimer's disease through attenuating brain oxidative damage in experimental mice
| Autor: | Elisabeth Ngo Bum, Willy Stéphane Nkemmo Touo’yem, Neteydji Sidiki, Sandrine Lauriane Ndjoulou Badiana, Esther Ngah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
biology Chemistry Monosodium glutamate Glutamate monosodium Ocimum basilicum Neuroprotection Oxidative stress Alzheimer disease Excitotoxicity Basilicum Glutamate receptor Neurotoxicity Pharmacology medicine.disease_cause Ocimum biology.organism_classification medicine.disease chemistry.chemical_compound food medicine |
| DOI: | 10.5281/zenodo.5650605 |
| Popis: | Ethnopharmacological relevance:Ocimum basilicumL. (Lamiaceae) is a medicinal plant known in Cameroon for the treatment of many ailments like anxiolytic, antispasmodic and mental disorders. Aim of the study:The aim of this study is to evaluate the neuroprotective effects ofOcimum basilicum. Materials and methods:T-maze test and open field test and the assay of oxidative stress parameters were used for detecting its capacity to protect neurons against excitotoxicity induced by monosodium glutamate. Results:It was found that theOcimum basilicumsignificantly increased the time spent in the preferred arm of the T-maze as well as the number of entries in the same arm. The first time arm choice latency decreased significantly in the animals treated by the compared to those treated with glutamate monosodium. In the open field test, it was noted an increase in the time spent in the center and the number of lines crossed. Results shows that the ofOcimum basilicumsignificantly reversed the oxidative damage induced by monosodium Glutamate by reducing the levels of MDA and increasing the concentration of CAT, GSH, SOD compared to the negative glutamate monosodium and distilled water treated groups respectively [F (5, 15) = 13.51; P < 0.001]; [F (5, 15) = 12.42; P < 0.001]; [F (6, 24) = 79.74; P < 0.001] and [F (5, 15) = 18.27; P < 0.001]. Conclusion:These results suggest thatOcimum basilicumpossess neuroprotectives properties in mice that might involve an action on antioxidant defense system in the central nervous system |
| Databáze: | OpenAIRE |
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