Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia
| Autor: | Mikio Tsuda, Keigo Nakagawa, Nobutaka Nagai, Ichiro Kodama, Mitsuhiro Sanada, Kazuaki Chayama, Koso Ohama, Yukihito Higashi |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Endothelium Vasodilator Agents Hypercholesterolemia General Biochemistry Genetics and Molecular Biology Nitroglycerin chemistry.chemical_compound Forearm Diabetes mellitus Internal medicine medicine Humans Reactive hyperemia Cholesterol business.industry Hypertriglyceridemia Obstetrics and Gynecology Middle Aged medicine.disease Plethysmography Postmenopause Vasodilation body regions Menopause medicine.anatomical_structure Endocrinology Premenopause chemistry Female Vascular Resistance lipids (amino acids peptides and proteins) Endothelium Vascular business Blood Flow Velocity Lipoprotein |
| Zdroj: | Maturitas. 44:307-315 |
| ISSN: | 0378-5122 |
| Popis: | We sought to determine whether menopausal status or postmenopausal hypercholesterolemia affects forearm resistance artery endothelial function. We studied the forearm resistance artery endothelial function in 75 Japanese women: 25 premenopausal volunteers, 25 postmenopausal women with normal serum low-density lipoprotein (LDL) cholesterol concentrations, and 25 hypercholesterolemic postmenopausal women. Excluded from the study were patients with hypertriglyceridemia, hypertension, or diabetes, cigarette smokers. The forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. The serum concentrations of lipoprotein (a) [Lp(a)] were significantly higher in the hypercholesterolemic postmenopausal group than in the other two groups (P |
| Databáze: | OpenAIRE |
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