Femoral bone defect healing using two novel biocompatible degradable materials
| Autor: | M. Skoric, Andrea Nečasová, Pavel Proks, Lucy Vojtová, Alois Nečas, Zita Filipejová, Robert Srnec |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Materials science prase 02 engineering and technology scaffold 010402 general chemistry Defect healing 01 natural sciences Animal model composite phosphate Pig General Veterinary animal model biomaterial biomateriál kompozit Biomaterial zvířecí model 021001 nanoscience & nanotechnology Biocompatible material fosfát 0104 chemical sciences Femoral bone 0210 nano-technology skafold Biomedical engineering |
| Zdroj: | ACTA VETERINARIA BRNO. 2020, vol. 89, issue 2, p. 163-169. |
| ISSN: | 1801-7576 0001-7213 |
| DOI: | 10.2754/avb202089020163 |
| Popis: | This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), and a porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%). Histological assessment showed a higher cell count in the place of bone defect in the control group compared to experimental groups. Between the experimental groups, a higher count of bone marrow cells was found in group EXP B. Both newly developed biomaterials seem to be suitable as replacements for large bone defects, having good workability and applicability. However, compared to the control group treated with a cancellous autograft, the newly formed bone did not reach the same number of cells settling in and in some cases, full radiological healing was not reached. Nevertheless, the material was found to be grown into the original bone in all cases within the experimental groups. The new biomaterials have a great potential as a substitute in the treatment of large bone defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|