Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells

Autor: R. Molino Lova, Claudio Macchi, Gian Franco Gensini, Roberta Boni, Chiara Castagnoli, Guido Pasquini, Silvia Pancani, Debora Valecchi, Anita Paperini, Rosanna Abbate, Federica Vannetti, Roberta Frandi, L. Razzolini, Francesca Cesari, Rossella Marcucci, Francesca Cecchi, Emilio Portaccio, Francesco Sofi, Anna Maria Gori, Nona Turcan
Rok vydání: 2017
Předmět:
Gerontology
Male
medicine.medical_specialty
Mediterranean diet
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Nutritional Status
Antigens
CD34
030204 cardiovascular system & hematology
Diet
Mediterranean
Recommended Dietary Allowances
Diet Surveys
Healthy Aging
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
Vegetables
medicine
Humans
030212 general & internal medicine
Endothelial dysfunction
Progenitor cell
Geriatric Assessment
Olive Oil
Endothelial Progenitor Cells
Aged
80 and over
Nutrition and Dietetics
business.industry
Confounding
Age Factors
Nutritional status
Feeding Behavior
Protective Factors
medicine.disease
Vascular Endothelial Growth Factor Receptor-2
Nutrition Assessment
Quartile
Italy
Fruit
Cohort
Female
Diet
Healthy
Cardiology and Cardiovascular Medicine
business
Nutritive Value
Risk Reduction Behavior
Biomarkers
Zdroj: Nutrition, metabolism, and cardiovascular diseases : NMCD. 28(1)
ISSN: 1590-3729
Popis: Background and aim Adherence to the Mediterranean Diet (MD) has been associated with a longer and better life. The aim of this study was to examine the effects of adherence to the MD, and of nutritional habits on endothelial progenitor (EPCs) and circulating progenitor (CPCs) cells in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status. Methods and Results Four hundred twenty-one nonagenarians (306 F, 115 M, mean age: 93.1 ± 3.2 years) were evaluated. Adherence to MD was assessed through the Mediterranean Diet Score. Elderly subjects who were in the fourth quartile of the Mediterranean diet score showed significantly higher EPCs than subjects grouped into the other three quartiles. After adjustment for confounders, elderly subjects who were in the highest quartile of adherence to the MD score reported to have EPCs' levels significantly higher than those who reported lower values of adherence to the MD. Furthermore, by analyzing different food categories, it was reported that daily consumption of olive oil and a higher consumption of fruit and vegetables showed higher CPCs CD34 + and EPCs CD34 + /KDR + than subjects with not daily or lower consumption. Conclusion Our results support the hypothesis that the adherence to MD, as well as a daily consumption of olive oil and fruit and vegetables, characteristics of MD, may protect against the development of endothelial dysfunction through increasing EPCs and CPCs in older age.
Databáze: OpenAIRE
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