Effects of atazanavir, darunavir, and raltegravir on fat and muscle among persons living with HIV
| Autor: | Kristine M. Erlandson, Jovana Milic, Enrica Roncaglia, Ann Scherzinger, Guido Ligabue, Barbara Beghetto, Stefan Adrian, Giulia Nardini, Jordan E. Lake, Giovanni Guaraldi, Han Feng, Hongyu Miao |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Anti-HIV Agents Atazanavir Sulfate Human immunodeficiency virus (HIV) HIV Infections Physical function medicine.disease_cause muscle density sarcopenia physical function Internal medicine Raltegravir Potassium medicine Humans Pharmacology (medical) skeletal muscle Hospitals Teaching Darunavir Retrospective Studies fat density business.industry Muscles Skeletal muscle Middle Aged Viral Load medicine.disease Raltegravir Antiretroviral therapy Atazanavir Infectious Diseases medicine.anatomical_structure Adipose Tissue Italy Sarcopenia HIV-1 Drug Therapy Combination Female business medicine.drug |
| Zdroj: | HIV researchclinical practice. 21(4) |
| ISSN: | 2578-7470 |
| Popis: | Antiretroviral therapy (ART) is associated with gain inParticipants from the Modena HIV Metabolic Clinic taking RAL, ATV/r, or DRV/r with at least 1 computed tomography (CT) scan were included. CT scans were reanalyzed for area and density of truncal fat and musculature. Multivariate models explored the effect of ART on fat and muscle density.One hundred six participants were receiving ATV/r, 48 DRV/r, and 141 RAL. In multivariate models (reference ATV/r), only DRV/r was associated with greater subcutaneous (SAT) and visceral adipose tissue (VAT) area, lower lateralis muscle density (more fat), and greater lateralis intermuscular fat area. Compared to ATV/r, RAL was independently associated with less psoas intermuscular fat area. Among all, greater paraspinal muscle density correlated with better physical function. No associations between ART group and physical function were seen among men; DRV/r was associated with stronger grip strength among women.DRV/r was associated with greater fat area and lower density of both fat and muscle, and RAL with less intermuscular psoas fat. Higher density psoas and paraspinal musculature were associated with better physical function, suggesting potential clinical relevance of these findings. |
| Databáze: | OpenAIRE |
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