Comparative cohort study of Duhamel and endorectal pull-through for Hirschsprung's disease
| Autor: | Joseph R. Davidson, Annika Mutanen, Malla Salli, Kristiina Kyrklund, Paolo De Coppi, Joe Curry, Simon Eaton, Mikko P. Pakarinen |
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| Přispěvatelé: | Clinicum, HUS Children and Adolescents, Children's Hospital, Lastenkirurgian yksikkö |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Adolescent CHILDHOOD GUIDELINES VALIDATION Cohort Studies Young Adult TERM BOWEL FUNCTION QUALITY-OF-LIFE COLOANAL ANASTOMOSIS SEXUAL FUNCTION Humans Hirschsprung Disease ENTEROCOLITIS Child Science & Technology Enterocolitis Rectum URINARY-TRACT SYMPTOMS General Medicine ADULTS 3126 Surgery anesthesiology intensive care radiology Child Preschool Quality of Life Surgery Life Sciences & Biomedicine |
| Popis: | Background There are limited data available to compare outcomes between surgical approaches for Hirschsprung’s disease. Duhamel and endorectal pull-through (ERPT) are two of the most common procedures performed worldwide. Methods Objective outcomes were compared between contemporary cohorts (aged 4–32 years) after Duhamel or ERPT using case–control methodology. Data were collected using prospectively administered standardized questionnaires on bowel and bladder function and quality of life (Pediatric Quality of Life Inventory, Short form 36 and Gastrointestinal Quality of Life Index). Patients were compared in two age groups (18 years and younger and older than 18 years) and reference made to normative control data. Multivariable analysis explored factors associated with poor outcomes. Results Cohorts were well matched by demographics, disease characteristics and incidence of postoperative complications (120 patients who underwent Duhamel versus 57 patients who had ERPT). Bowel function scores were similar between groups. Patients who underwent Duhamel demonstrated worse constipation and inferior faecal awareness scores (P Conclusion Outcomes from Duhamel and ERPT are good in the majority of cases, with comparable bowel function scores. Constipation and impaired faecal awareness were more prevalent after Duhamel, with differences sustained in adulthood. Recurrent enterocolitis was significantly more prevalent after ERPT. Clustering of poor QoL and poor functional outcomes were observed in both cohorts, with seemingly little effect by choice of surgical procedure in terms of QoL. |
| Databáze: | OpenAIRE |
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