Left ventricular dilatation and failure post-myocardial infarction: Pathophysiology and possible pharmacologic interventions

Autor: Brian G. Firth, Preston M. Dunnmon
Rok vydání: 1990
Předmět:
Zdroj: Cardiovascular Drugs and Therapy. 4:1363-1374
ISSN: 1573-7241
0920-3206
DOI: 10.1007/bf02018264
Popis: An important antecedent to the development of late congestive heart failure is left ventricular dilatation and remodeling following myocardial infarction, which occurs in 30-40% of acute anterior transmural infarcts. Dilatation and remodeling commence within the first 24 hours following myocardial infarction and may be steadily progressive over months to years. Both the infarcted and uninfarcted regions of the myocardium are equally involved in the process. The remodeling process comprises left ventricular wall thinning (mainly due to cell slippage), chamber dilatation, and compensatory hypertrophy of the uninfarcted segment of the myocardium. The hypertrophy may initially be physiologic but may ultimately become a pathologic process, and thereby contribute to pump dysfunction. The possible reasons why the ventricular hypertrophy may ultimately be dysfunctional include alterations in local architecture and their sequelae alone or in concert with local changes in the beta-adrenergic, alpha-adrenergic, or renin angiotensin systems. At the present time, there are encouraging data to suggest that nitroglycerin, or the angiotensin converting enzyme inhibitor captopril, may ameliorate this process.
Databáze: OpenAIRE
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