Deep anterior lamellar keratoplasty using acellular corneal tissue for prevention of allograft rejection in high-risk corneas
| Autor: | Lihua Wang, Zifeng Deng, Wei Chen, Huixiang Ma, Jinyang Li, Li Sun, Lechu Yu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Glycerol Graft Rejection Male medicine.medical_specialty Visual acuity Adolescent Eye Infections Visual Acuity Cell Count Keratitis Corneal Diseases Cornea Corneal Transplantation Young Adult Double-Blind Method medicine Humans Transplantation Homologous Fungal keratitis Prospective Studies Prospective cohort study Survival analysis Aged Microscopy Confocal business.industry Endothelium Corneal Graft Survival Organ Preservation Middle Aged medicine.disease eye diseases Tissue Donors Surgery Transplantation Ophthalmology Eye Burns medicine.anatomical_structure Population study Female sense organs medicine.symptom business |
| Zdroj: | American journal of ophthalmology. 152(5) |
| ISSN: | 1879-1891 |
| Popis: | Purpose To determine whether deep anterior lamellar keratoplasty (DALK) using acellular glycerol-cryopreserved corneal tissue (GCCT) could prevent allograft rejection in high-risk corneas. Design Prospective, randomized, comparative study. Methods settings: The Eye Hospital, Wenzhou Medical College, Zhejiang, China. study population: All patients with herpes simplex virus keratitis, bacterial keratitis, fungal keratitis, or ocular burn, who were eligible as per study design, were invited to participate. observation procedures: According to randomized block design, all patients received either GCCT or fresh corneal tissue (FCT) during DALK. Best-corrected visual acuity (BCVA), slit-lamp microscopy, and in vivo confocal microscopy examinations at 1 week and 1, 3, 6, 12, and 24 months after surgery were analyzed. Kaplan-Meier survival analysis was used to evaluate graft survival rate. main outcome measures: Therapeutic success, 2-year rejection-free graft survival rate and 2-year graft survival rate, in vivo confocal microscopy results, BCVA, and endothelial cell density. Results Postoperative BCVA of 20/40 or better at the last follow-up visit was achieved in 57.6% (19/33) of eyes in the GCCT group and in 54.8% (17/31) of the FCT group. No graft rejection occurred in the GCCT group, while in the FCT group 10 episodes of stromal rejection developed in 7 eyes. Overall, the rejection-free graft survival rate at 2 years was significantly higher in the GCCT group as compared with the FCT group (100.0%, 78.8% respectively, P = .006). Conclusions Deep anterior lamellar keratoplasty using acellular glycerol-preserved cornea could prevent allograft rejection and promote graft survival rate in high-risk corneas. |
| Databáze: | OpenAIRE |
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