Pharmacological Study on Arctostaphylos uva-ursi (L.) SPRENG. II. Combined Effects of Arbutin and Prednisolone or Dexamethazone on Immuno-inflammation
| Autor: | Haruka Nakata, Michinori Kubo, Takayuki Tanaka, Hideaki Matsuda |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Prednisolone Pharmaceutical Science chemical and pharmacologic phenomena Spleen Inflammation Picryl Chloride Pharmacology Dermatitis Contact Dexamethasone Picryl chloride Mice chemistry.chemical_compound medicine Animals Hypersensitivity Delayed Glycosides chemistry.chemical_classification Red Cell Arbutin Glycoside medicine.disease medicine.anatomical_structure chemistry Drug Therapy Combination Female medicine.symptom Contact dermatitis medicine.drug |
| Zdroj: | YAKUGAKU ZASSHI. 110:68-76 |
| ISSN: | 1347-5231 0031-6903 |
| Popis: | A study was carried out to examine the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and prednisolone or dexamethazone on Type IV allergic reaction-induced immuno-inflammation. Contact dermatitis caused by picryl chloride (PC-CD) and sheep red cell delayed type hypersensitivity (SRBC-DTH) in mice was not inhibited by the oral application of arbutin at 2 divided doses immediately before and 16 h after the application, but arbutin at doses of 10, 50 mg/kg 24 h after the application speedily decreased the swelling of PC-CD and SRBC-DTH. Arbutin plus prednisolone or dexamethazone showed the inhibitory effect on the swelling of PC-CD and SRBC-DTH stronger than that of prednisolone or dexamethazone alone. Prednisolone and dexamethazone decreased the weight of thymus and spleen in intact, PC-CD and SRBC-DTH mice, but arbutin did not show these effects. These results suggest that arbutin may increase the inhibitory action of prednisolone and dexamethazone on PC-CD and SRBC-DTH, but further investigations are required to understand the mechanism involved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|