The leading established metal-based drugs: a revisitation of their relevant physico-chemical data
| Autor: | Lorenzo Ciofi, Maria Giulia Fabbrini, Luigi Messori, Lara Massai, Tiziano Marzo, Alessandro Pratesi, Damiano Cirri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology toxicology
General Biochemistry Genetics and Molecular Biology Gold Sodium Thiomalate Ruthenium Bioinorganic chemistry Carboplatin Biomaterials 03 medical and health sciences Clinical compounds Coordination compounds Medicinal inorganic complexes Metal based drugs Coordination Complexes Auranofin 030304 developmental biology Platinum 0303 health sciences Chemistry 030302 biochemistry & molecular biology Metals and Alloys Chemical data Thimerosal Mercury Phenylmercury Compounds Combinatorial chemistry Oxaliplatin Gold Cisplatin General Agricultural and Biological Sciences Merbromin |
| Zdroj: | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 32(5) |
| ISSN: | 1572-8773 |
| Popis: | The study of metal-based drugs represents an important branch of modern bioinorganic chemistry. The growing importance of this field is linked to the large success in medicine of a few metal based drugs, either in clinical use or still experimental. Moreover, these metal-based drugs are frequently used as reference compounds to assess comparatively the behavior of newly synthesized metallodrugs. For the convenience of researchers working in this area we report here a compilation of the relevant analytical and spectroscopic data of ten representative metallodrugs based on Platinum, Ruthenium, Gold and Mercury. The selected compounds, namely Cisplatin, Oxaliplatin, Carboplatin, Auranofin, Sodium Aurothiomalate, NAMI-A, KP1019, Thimerosal, Merbromin and Phenylmercury Acetate, were chosen owing to their importance in the field. We believe that this compilation may turn very helpful to researchers as these data are difficult to find and generally scattered over a large number of (old) publications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink