Association of schistosomiasis and HIV infections: A systematic review and meta-analysis
| Autor: | W. Evan Secor, Jennifer A. Downs, Charles E. Rose, Pragna Patel, D. Heather Watts, Eyrun Floerecke Kjetland, Wairimu Chege, Keith Sabin, Pamela Sabina Mbabazi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Female circumcision medicine.medical_specialty 030106 microbiology Human immunodeficiency virus (HIV) HIV Infections Schistosomiasis medicine.disease_cause lcsh:Infectious and parasitic diseases Association 03 medical and health sciences 0302 clinical medicine Internal medicine Prevalence medicine Humans lcsh:RC109-216 030212 general & internal medicine Mass drug administration Africa South of the Sahara Sub-Saharan Africa business.industry Transmission (medicine) Hazard ratio HIV Bayes Theorem General Medicine Odds ratio medicine.disease Infectious Diseases Meta-analysis Mass Drug Administration Female business |
| Zdroj: | International Journal of Infectious Diseases, Vol 102, Iss, Pp 544-553 (2021) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2020.10.088 |
| Popis: | Background Female genital schistosomiasis (FGS) affects up to 56 million women in sub-Saharan Africa and may increase risk of HIV infection. Methods To assess the association of schistosomiasis with HIV infection, peer-reviewed literature published until 31 December 2018 was examined and a pooled estimate for the odds ratio was generated using Bayesian random effects models. Results Of the 364 abstracts that were identified, 26 were included in the summary. Eight reported odds ratios of the association between schistosomiasis and HIV; one reported a transmission hazard ratio of 1.8 (95% CI, 1.2–2.6) among women and 1.4 (95% CI, 1.0–1.9) among men; 11 described the prevalence of schistosomiasis among HIV-positive people (range, 1.5–36.6%); and six reported the prevalence of HIV among people with schistosomiasis (range, 5.8–57.3%). Six studies were selected for quantitative analysis. The pooled estimate for the odds ratio of HIV among people with schistosomiasis was 2.3 (95% CI, 1.2–4.3). Conclusions A significant association of schistosomiasis with HIV was found. However, a specific summary estimate for FGS could not be generated. A research agenda was provided to determine the effect of FGS on HIV infection. The WHO’s policy on mass drug administration for schistosomiasis may prevent HIV. |
| Databáze: | OpenAIRE |
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