Reliability of clonidine testing for the diagnosis of growth hormone deficiency in children and adolescents
| Autor: | Chiara Guzzetti, Sandro Loche, Mariacarolina Salerno, Anastasia Ibba, Anna Allegri, Marco Cappa, Mohamad Maghnie, Natascia Di Iorgi, Letizia Casula |
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| Přispěvatelé: | Ibba, A., Guzzetti, C., Casula, L., Salerno, M., Di Iorgi, N., Allegri, A. M. E., Cappa, M., Maghnie, M., Loche, S. |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Endocrinology Diabetes and Metabolism Short Stature 030209 endocrinology & metabolism Short stature Clonidine Body Mass Index Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine children clonidine GH GH deficiency short stature medicine Humans Endocrine system 030212 general & internal medicine Insulin-Like Growth Factor I Child Dwarfism Pituitary Children Retrospective Studies GH GH deficiency Human Growth Hormone business.industry Puberty Retrospective cohort study medicine.disease Growth hormone secretion Female medicine.symptom business GH Deficiency medicine.drug |
| Zdroj: | Clinical Endocrinology. 89:765-770 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/cen.13845 |
| Popis: | OBJECTIVE: The diagnosis of growth hormone deficiency (GHD) is currently based on clinical, auxological, biochemical and neuro-radiological investigation. Provocative tests of GH secretion using physiological/pharmacological stimuli are required to confirm GHD. The clonidine test (CT) is widely used to assess GH secretory status. In this retrospective study, we analyzed the reliability of CT and the effect of puberty in a large number of children with short stature who had been evaluated for suspected GHD. DESIGN AND PATIENTS: Data were collected retrospectively from 327 children and adolescents with short stature (204 boys and 123 girls, median age 10.5 years (IQR 7.90-12.40) followed in four Italian Paediatric Endocrine Units (Cagliari, Genova, Napoli and Roma) between 2005 and 2013. MEASUREMENTS: All children underwent CT as the first GH stimulation test after exclusion of other known cause of their short stature. RESULTS: In 73 prepubertal children and 25 pubertal children, the GH peak after CT was |
| Databáze: | OpenAIRE |
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