Regulation of signal transduction by reactive oxygen species in the cardiovascular system
| Autor: | David Brown, Kathy Griendling |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Senescence Reactive oxygen species Physiology Angiogenesis Endoplasmic reticulum Biology medicine.disease_cause Cardiovascular System Article Muscle hypertrophy Cell biology Oxidative Stress chemistry Apoptosis medicine Animals Humans Signal transduction Cardiology and Cardiovascular Medicine Reactive Oxygen Species Oxidative stress Signal Transduction |
| Zdroj: | Circulation research. 116(3) |
| ISSN: | 1524-4571 |
| Popis: | Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species in normal physiological signaling has been elucidated. Signaling pathways modulated by reactive oxygen species (ROS) are complex and compartmentalized, and we are only beginning to identify the molecular modifications of specific targets. Here we review the current literature regarding ROS signaling in the cardiovascular system, focusing on the role of ROS in normal physiology and how dysregulation of signaling circuits contributes to cardiovascular diseases including atherosclerosis, ischemia-reperfusion injury, cardiomyopathy and heart failure. In particular, we consider how ROS modulate signaling pathways related to phenotypic modulation, migration and adhesion, contractility, proliferation and hypertrophy, angiogenesis, endoplasmic reticulum stress, apoptosis and senescence. Understanding the specific targets of ROS may guide the development of the next generation of ROS-modifying therapies to reduce morbidity and mortality associated with oxidative stress. |
| Databáze: | OpenAIRE |
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