Electroconvulsive Shock Increases Tyrosine Hydroxylase Activity in the Brain and Adrenal Gland of the Rat
Autor: | Joseph M. Masserano, Norman Weiner, Glenn S. Takimoto |
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Rok vydání: | 1981 |
Předmět: |
Male
Cerebellum medicine.medical_specialty Time Factors Tyrosine 3-Monooxygenase Hippocampus Striatum Internal medicine Adrenal Glands medicine Animals Enzyme inducer Electroshock Multidisciplinary biology Adrenal gland business.industry Locus Ceruleus Brain Rats Inbred Strains Corpus Striatum Rats medicine.anatomical_structure Endocrinology Enzyme Induction biology.protein Antidepressant Locus Coeruleus business Adrenal medulla |
Zdroj: | Science. 214:662-665 |
ISSN: | 1095-9203 0036-8075 |
Popis: | A single application of electroconvulsive shock produced a rapid but short-lasting increase in tyrosine hydroxylase activity above control values in the rat adrenal medulla and striatum. After repeated electroconvulsive shock treatment (once per day for 7 days), tyrosine hydroxylase activity increased significantly in the locus ceruleus, nucleus of the tractus solitarius, hippocampus, cerebellum, and frontal cortex and remained elevated for 4 to 8 days. Adrenal tyrosine hydroxylase activity increased 1 day after the termination of repeated electroconvulsive shock treatments and remained elevated for at least 24 days, possibly reflecting the establishment of a new and higher steady-state level of catecholamine biosynthesis in the adrenal. These findings suggest that the persistent changes in tyrosine hydroxylase activity produced by repeated electroconvulsive shock may be a factor contributing to the long-lasting antidepressant effects of this treatment. |
Databáze: | OpenAIRE |
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