Stretch modulation of cardiac contractility: importance of myocyte calcium during the slow force response
| Autor: | Amelia Power, Sarbjot Kaur, Marie-Louise Ward, Xin Shen |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Contraction (grammar) Chemistry Biophysics Diastole chemistry.chemical_element Review Stretch activated channels Calcium 010402 general chemistry 01 natural sciences 0104 chemical sciences Contractility 03 medical and health sciences Structural Biology Myocyte Molecular Biology Calcium influx Rapid response 030304 developmental biology |
| ISSN: | 1867-2450 |
| Popis: | The mechanical response of the heart to myocardial stretch has been understood since the work of muscle physiologists more than 100 years ago, whereby an increase in ventricular chamber filling during diastole increases the subsequent force of contraction. The stretch-induced increase in contraction is biphasic. There is an abrupt increase in the force that coincides with the stretch (the rapid response), which is then followed by a slower response that develops over several minutes (the slow force response, or SFR). The SFR is associated with a progressive increase in the magnitude of the Ca(2+) transient, the event that initiates myocyte cross-bridge cycling and force development. However, the mechanisms underlying the stretch-dependent increase in the Ca(2+) transient are still debated. This review outlines recent literature on the SFR and summarizes the different stretch-activated Ca(2+) entry pathways. The SFR might result from a combination of several different cellular mechanisms initiated in response to activation of different cellular stretch sensors. |
| Databáze: | OpenAIRE |
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