Remotely Controlled Proton Generation for Neuromodulation
| Autor: | Polina Anikeeva, Anthony Tabet, Jimin Park, Atharva Sahasrabudhe, Florian Koehler, Po Han Chiang, Junsang Moon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Proton
Bioengineering 02 engineering and technology Ph changes Calcium in biology Article Magnetics Extracellular General Materials Science Ion channel Acid-sensing ion channel Chemistry Mechanical Engineering fungi General Chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Condensed Matter Physics equipment and supplies Neuromodulation (medicine) Magnetic Fields Biophysics Magnetic nanoparticles Nanoparticles Protons 0210 nano-technology |
| Zdroj: | Nano Lett |
| DOI: | 10.26434/chemrxiv.12369893.v1 |
| Popis: | Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting non-invasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signalling in the nervous system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|