Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome
| Autor: | Noriko Satoh, Takafumi Majima, Kazuhiko Kotani, Akira Shimatsu, Kazunori Yamada, Akihiro Himeno, Yoshihiro Ogawa, Takayoshi Suganami |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Physiology Enzyme-Linked Immunosorbent Assay Biology Internal medicine Internal Medicine medicine Humans Ankle Brachial Index Single-Blind Method Serum amyloid A Pulse wave velocity Hypolipidemic Agents Metabolic Syndrome Serum Amyloid A Protein Adiponectin Leptin Arteries Middle Aged medicine.disease Eicosapentaenoic acid Lipoproteins LDL Endocrinology Eicosapentaenoic Acid Regional Blood Flow Arterial stiffness Female lipids (amino acids peptides and proteins) Metabolic syndrome Cardiology and Cardiovascular Medicine Algorithms Lipoprotein |
| Zdroj: | Hypertension Research. 32:1004-1008 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1038/hr.2009.145 |
| Popis: | A recent clinical trial revealed that highly purified eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, reduces the incidence of cardiovascular diseases. However, the detailed mechanism underlying the anti-atherogenic effect of EPA is still poorly understood. In this study, we examined the effect of EPA on cardio-ankle vascular index (CAVI), a new index of arterial stiffness that is less influenced by blood pressure (BP), as well as on serum amyloid A-low-density lipoprotein (SAA-LDL), an oxidized LDL (oxLDL), in the metabolic syndrome. Ninety-two obese Japanese subjects with metabolic syndromes were randomly divided into two groups (n=46): the EPA-treated group (1.8 g administered daily for 3 months) and the control group. Measurements were taken to assess the changes in glucose-lipid metabolism, SAA-LDL, C-reactive protein (CRP), leptin, adiponectin and pulse wave velocity (PWV), and CAVI. EPA treatment significantly reduced the levels of immunoreactive insulin, triglycerides, SAA-LDL, CRP, PWV and CAVI and increased the levels of adiponectin relative to the control group for 3 months (P |
| Databáze: | OpenAIRE |
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