Ophthalmic Assessment in Patients With Darier Disease
| Autor: | Helwe Hammad, Michael Ziv, Daniel Briscoe, Shiraz Vered, Eldad Adler, Algit Yeshurun, Roni P. Dodiuk-Gad, Lena Abayev |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Conjunctiva Visual acuity Adolescent genetic structures Visual Acuity Meibomian gland Refraction Ocular Slit Lamp Microscopy Conjunctival Diseases Corneal Diseases Ophthalmic pathology 03 medical and health sciences 0302 clinical medicine Darier Disease Surveys and Questionnaires Cornea Prevalence Humans Medicine Prospective Studies Blepharitis Prospective cohort study Aged 030304 developmental biology Aged 80 and over 0303 health sciences business.industry Middle Aged medicine.disease Dermatology eye diseases Ophthalmology medicine.anatomical_structure Eyelid Diseases 030221 ophthalmology & optometry Dry Eye Syndromes Female sense organs medicine.symptom business |
| Zdroj: | American Journal of Ophthalmology. 227:139-142 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2021.03.011 |
| Popis: | Purpose To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease. Design Prospective observational case series. Methods Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted. Results According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age. Conclusions The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect