Synchronous indolent primary gastrointestinal lymphomas managed successfully with conservative measures
| Autor: | Barry L. Gause, Ron Lieberman, Joo Y. Song, Andrew S. Brohl |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Follicular lymphoma Gastroenterology Epigastric pain Article Helicobacter Infections Neoplasms Multiple Primary immune system diseases Stomach Neoplasms Internal medicine hemic and lymphatic diseases Biopsy medicine Humans Pharmacology (medical) B cell Aged Pharmacology biology medicine.diagnostic_test Helicobacter pylori business.industry digestive oral and skin physiology Proton Pump Inhibitors General Medicine Lymphoma B-Cell Marginal Zone biology.organism_classification medicine.disease Lymphoma Endoscopy Anti-Bacterial Agents Regimen medicine.anatomical_structure Drug Therapy Combination business |
| Zdroj: | American journal of therapeutics. 20(5) |
| ISSN: | 1536-3686 |
| Popis: | We report the case of a 65-year-old man who presented with epigastric pain and guaic-positive stool. Upper and lower endoscopy revealed abnormalities in the gastric antrum and terminal ileum. Biopsy of these sites revealed histologically and immunophenotypically distinct lymphomas: gastric extranodal marginal zone lymphoma in the background of Helicobacter pylori infection and follicular lymphoma of the terminal ileum. After treatment with an H. pylori eradication regimen, repeat endoscopy showed resolution of the gastric extranodal marginal zone lymphoma and persistence of the ileal follicular lymphoma. Interestingly, molecular studies performed on the biopsy specimens revealed a common IgH rearrangement, suggesting a common precursor cell responsible for these two malignant processes. We present this unique case with a review of the literature, highlighting treatment principles for these two subtypes of indolent gastrointestinal non-Hodgkin lymphoma. |
| Databáze: | OpenAIRE |
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