Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients
| Autor: | B A C Dijkmans, Paul Lips, A E Voskuyl, H G Raterman, Marco W.J. Schreurs, V P van Halm, Suat Simsek, Marjolein Peters, I M W van Hoogstraten, Michael T. Nurmohamed, W.F. Lems |
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| Přispěvatelé: | Cardiology, Immunology, Rheumatology, Internal medicine, Pathology, CCA - Immuno-pathogenesis, ICaR - Circulation and metabolism, MOVE Research Institute, Research Institute MOVE |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Thyroid Hormones Carotid Artery Common Endocrinology Diabetes and Metabolism Disease Carotid Intima-Media Thickness Iodide Peroxidase Risk Assessment Arthritis Rheumatoid Endocrinology Hypothyroidism SDG 3 - Good Health and Well-being Thyroid peroxidase Risk Factors Internal medicine Medicine Humans Prospective Studies Prospective cohort study Aged Autoantibodies biology business.industry Autoantibody General Medicine Middle Aged medicine.disease Intima-media thickness Cardiovascular Diseases Rheumatoid arthritis biology.protein Disease Progression Disease characteristics Female business Risk assessment Biomarkers |
| Zdroj: | Raterman, H G, Voskuyl, A E, Simsek, S, Schreurs, M W J, van Hoogstraten, I M W, Peters, M J L, van Halm, V P, Dijkmans, B A C, Lips, P, Lems, W F & Nurmohamed, M T 2013, ' Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients ', European Journal of Endocrinology, vol. 169, no. 6, pp. 751-757 . https://doi.org/10.1530/EJE-13-0394 European journal of endocrinology / European Federation of Endocrine Societies, 169(6), 751-757. BioScientifica Ltd. European Journal of Endocrinology, 169(6), 751-757. Bioscientifica Ltd European Journal of Endocrinology, 169(6), 751-757. BioScientifica Ltd. |
| ISSN: | 0804-4643 |
| Popis: | ObjectiveAutoimmune diseases such as rheumatoid arthritis (RA) and hypothyroidism tend to cluster, and this coexistence amplifies the elevated cardiovascular risk in RA. Whether thyroid peroxidase antibodies (TPOabs) are associated with increased cardiovascular disease (CVD) risk has not been studied extensively. Therefore, this study determined firstly the prevalence of TPOabs in RA and secondly whether TPOabs were associated with CVD. Moreover, this study explored whether TPOabs were related to RA characteristics.Design and methodsData from the CARRÉ Study, an ongoing study investigating CVDs and its risk factors in RA (n=322), was used to ascertain the prevalence of TPOabs in RA patients. In addition, cardiovascular and RA disease characteristics were compared between TPOabs-positive and -negative patients at baseline and at a second visit after 3 years.ResultsTPOabs were present in 47/322 (15%) RA patients and TSH levels were higher in TPOabs-positive patients (1.40 mU/l) compared with TPOabs-negative patients (1.26 mU/l, P=0.048). At baseline and after 3 years no association was observed between TPOabs and (risk factors for) CVD. Regression analyses revealed a significantly larger progression of carotid intima media thickness (cIMT; β=0.13 mm) in TPOabs-positive compared with TPOabs-negative patients independent of risk factors for cIMT progression. RA disease activity scores (DAS28) were higher in TPOabs-positive compared with TPOabs-negative patients (4.4 vs 3.8 P=0.018).ConclusionsTPOabs were associated with increased cIMT progression. Moreover, an association between TPOabs and DAS28 was observed. Hence, TPOabs seems to have a role in the amplified cardiovascular risk in RA patients. |
| Databáze: | OpenAIRE |
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