Effect of 5-HT2C receptor antagonist RS 102221 on mouse behavior
| Autor: | Tamara G. Amstislavskaya, E. G. Kuznetsova, E. A. Shefer, N. K. Popova |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Reflex Startle medicine.medical_specialty medicine.drug_class RS-102221 Anxiety Motor Activity Anxiolytic Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Open field Mice chemistry.chemical_compound Internal medicine Moro reflex medicine Animals Spiro Compounds Receptor Sulfonamides Dose-Response Relationship Drug Antagonist General Medicine 5-HT2C receptor Endocrinology chemistry Anesthesia Mice Inbred CBA Serotonin Serotonin 5-HT2 Receptor Agonists |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 142:76-79 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-006-0296-8 |
| Popis: | Injection of RS 102221 (selective antagonist of serotonin 5-HT2C receptors) in a dose of 2 mg/kg reduced anxiety of mice in the light-darkness test and decreased the amplitude of the startle reflex. RS 102221 in a dose of 1 mg/kg reduced prestimulus inhibition of the startle reflex. No behavioral changes in Porsolt test and motor activity in the open field test were detected. Hence, RS 102221 is characterized by selective anxiolytic activity, and 5-HT2C receptors are involved in the mechanisms of anxiety and startle reflex formation. |
| Databáze: | OpenAIRE |
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