Larazotide acetate: a pharmacological peptide approach to tight junction regulation
| Autor: | Zachary M. Slifer, Anthony T. Blikslager, B Radha Krishnan, Jay Madan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Myosin light-chain kinase Tight Junction Proteins Hepatology Tight junction Physiology Chemistry Gastroenterology Zonulin Peptide Permeability Cell biology Amino acid Tight Junctions Celiac Disease Larazotide Physiology (medical) Animals Humans Oligopeptides Barrier function Actin |
| Zdroj: | American journal of physiology. Gastrointestinal and liver physiology. 320(6) |
| ISSN: | 1522-1547 |
| Popis: | Larazotide acetate (LA) is a single-chain peptide of eight amino acids that acts as a tight junction regulator to restore intestinal barrier function. LA is currently being studied in phase III clinical trials and is orally administered to adult patients with celiac disease as an adjunct therapeutic to enhance intestinal barrier function that has been disrupted by gliadin-induced immune reactivity. Mechanistically, LA is thought to act as a zonulin antagonist to reduce zonulin-induced increases in barrier permeability and has been associated with the redistribution and rearrangement of tight junction proteins and actin filaments to restore intestinal barrier function. More recently, LA has been linked to inhibition of myosin light chain kinase, which likely reduces tension on actin filaments, thereby facilitating tight junction closure. Small (rodent) and large (porcine) animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|