Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115

Autor:	Nicole Tessot, Jacques Demassey, Periers Anne-Marie, Fabienne Chatreaux, Yannick Benedetti, Jean Khider, Patrick Laurin, Marlene Airault, Michel Klich, Alain Bonnefoy, Pascale Vicat, Branislav Musicki, Didier Ferroud, Patrice Lassaigne, Claudine Dupuis-Hamelin, Jean-Luc Haesslein, Christine Pierre, Alain Iltis, Sylvette Lachaud
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Microbial Sensitivity Tests Coumarin Biochemistry Chemical synthesis DNA gyrase Anti-Bacterial Agents chemistry.chemical_compound Anti-Infective Agents In vivo Coumarins Drug Discovery Molecular Medicine heterocyclic compounds Antibacterial activity Molecular Biology Lactone Antibacterial agent Hexoses
Zdroj:	Bioorganicmedicinal chemistry letters. 10(15)
ISSN:	0960-894X
Popis:	A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5'5'-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc5a71cfbe94e9672b3fc999488bf53 https://pubmed.ncbi.nlm.nih.gov/10937727 Zobrazit plný text záznamu Full Text from ScienceDirect