Real-time polymerase chain reaction testing for Clostridium difficile reduces isolation time and improves patient management in a small community hospital
| Autor: | Justin Cirone, Mary Catanzaro |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Epidemiology Clostridium difficile toxin A Hospitals Community Real-Time Polymerase Chain Reaction Patient Isolation Patient satisfaction Vancomycin Metronidazole Internal medicine medicine Humans Infection control Aged Retrospective Studies Aged 80 and over Clostridioides difficile business.industry Health Policy Incidence (epidemiology) Public Health Environmental and Occupational Health Clostridium difficile Drug Utilization Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases Real-time polymerase chain reaction Molecular Diagnostic Techniques Clostridium Infections Female business medicine.drug |
| Zdroj: | American Journal of Infection Control. 40:663-666 |
| ISSN: | 0196-6553 |
| Popis: | The impact of a switch from a toxin A/B enzyme immunoassay (EIA) to a polymerase chain reaction (PCR) method for detection of toxigenic Clostridium difficile was assessed for C difficile infection (CDI) rates, patient isolation-days, and CDI-related treatment.A 6-month retrospective study was done on symptomatic patients tested by the toxin A/B EIA and PCR assays. Data on the number of C difficile tests ordered, patient isolation-days, and treatment with metronidazole or vancomycin were collected. CDI rates were reported as cases per 10,000 patient-days, and differences between both groups were compared by χ(2) and Z-test analysis.The CDI incidence was 11.2 and 12.7/10,000 patient-days in the EIA and PCR test periods, respectively (P = .36). Health care-associated CDI decreased from 4.4 per 10,000 patient-days during EIA testing to 0.9 per 10,000 patient-days during PCR testing (P = .02). A significant decrease in patient isolation-days (P.00001), tests ordered (P = .002), and metronidazole treatment for patients with a negative C difficile test (P = .02) was observed with PCR testing.PCR testing is a viable option for small community hospitals, providing accurate and timely results for patient management and infection control. This can potentially lead to improved outcomes, increased patient satisfaction, and significant hospital cost savings. |
| Databáze: | OpenAIRE |
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