Meningiomas from a developmental perspective: exploring the crossroads between meningeal embryology and tumorigenesis
| Autor: | Michel Kalamarides, Matthieu Peyre, Julien Boetto |
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| Rok vydání: | 2020 |
| Předmět: |
Future studies
Carcinogenesis Cell of origin medicine.disease_cause 030218 nuclear medicine & medical imaging Meningioma 03 medical and health sciences Meninges 0302 clinical medicine Meningeal Neoplasms otorhinolaryngologic diseases Animals Humans Medicine neoplasms business.industry Embryonic Tissue medicine.disease Embryonic stem cell nervous system diseases Cell Transformation Neoplastic medicine.anatomical_structure Embryology Surgery Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Acta Neurochirurgica. 163:57-66 |
| ISSN: | 0942-0940 0001-6268 |
| Popis: | Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningeal embryology and tumorigenesis. In this non-systematic review, we summarize the current knowledge on meningeal embryology and developmental biology, and illustrate how meningioma tumorigenesis is deeply related to meningeal embryology, concerning the potential cell of origin, the role of reactivation of embryonic stem cells, the influence of the embryonic tissue of origin, and the parallelism between topography-dependant molecular pathways involved in normal meninges and in meningioma development. Our study emphasizes why future studies on meningeal embryology are mandatory to affine our comprehension of mechanisms underlying meningioma initiation and development. |
| Databáze: | OpenAIRE |
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