Use of a Flexible Inflatable Multi-Channel Applicator for Vaginal Brachytherapy in the Management of Gynecologic Cancer
| Autor: | John P. Curtin, Stella C. Lymberis, S. Shin, Benjamin T. Cooper, Peter B. Schiff, T. Duckworth, J. Keith DeWyngaert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Simultaneous integrated boost
CapriTM medicine.medical_specialty Cancer Research medicine.medical_treatment Brachytherapy Rectum multi-channel vaginal applicator lcsh:RC254-282 single-channel applicator Gynecologic cancer medicine Dosimetry interstitial implant Interstitial implant Original Research business.industry toxicity lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery medicine.anatomical_structure Oncology Vagina Implant Nuclear medicine business |
| Zdroj: | Frontiers in Oncology, Vol 5 (2015) Frontiers in Oncology |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2015.00201 |
| Popis: | Introduction Evaluate use of novel multi-channel applicator (MC) Capri™ to improve vaginal disease coverage achievable by single-channel applicator (SC) and comparable to Syed plan simulation. Materials and methods Twenty-eight plans were evaluated from four patients with primary or recurrent gynecologic cancer in the vagina. Each received whole pelvis radiation, followed by three weekly treatments using HDR brachytherapy with a 13-channel MC. Upper vagina was treated to 5 mm depth to 1500 cGy/3 fractions with a simultaneous integrated boost totaling 2100 cGy/3 fractions to tumor. Modeling of SC and Syed plans was performed using MC scans for each patient. Dosimetry for MC and SC plans was evaluated for PTV700 cGy coverage, maximum dose to 2 cm3 to bladder, rectum, as well as mucosal surface points. Dosimetry for Syed plans was calculated for PTV700 cGy coverage. Patients were followed for treatment response and toxicity. Results Dosimetric analysis between MC and SC plans demonstrated increased tumor coverage (PTV700 cGy), with decreased rectal, bladder, and contralateral vaginal mucosa dose in favor of MC. These differences were significant (p |
| Databáze: | OpenAIRE |
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