Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock
| Autor: | J. C. Ruiz, R. Sauri, J. Gómez-Jiménez, F. Esteban, A. Salgado, X. Nuvials, Manuel Campo Martín, R. Peracaula, J L Bóveda, R. M. Segura |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Lipopolysaccharides Male Lipopolysaccharide Adolescent Inflammation Neopterin Monocytes Proinflammatory cytokine chemistry.chemical_compound medicine Immunology and Allergy Humans Prospective Studies APACHE Aged Aged 80 and over Septic shock business.industry Monocyte Macrophages Interleukin Middle Aged medicine.disease Biopterin Shock Septic Interleukin-10 Infectious Diseases medicine.anatomical_structure chemistry Immunology Cytokines Tumor necrosis factor alpha Female medicine.symptom business |
| Zdroj: | The Journal of infectious diseases. 171(2) |
| ISSN: | 0022-1899 |
| Popis: | Interleukin (IL)-10 is a potent immunosuppressant of monocyte/macrophage function and may help control the inflammatory response induced by bacterial infection. To analyze whether IL-10 is detectable in plasma of patients with septic shock and to evaluate its relationship with endotoxin (lipopolysaccharide [LPS])-induced and monocyte/macrophage-induced inflammatory response, plasma IL-10, tumor necrosis factor (TNF)-alpha, IL-1 beta, IL-6, IL-8, LPS, and neopterin were studied in 24 patients with septic shock and in 12 critically ill patients. Eighty-three percent of patients with septic shock and 25% of critically ill patients had detectable levels of IL-10 (P < .001). There was a significant correlation between plasma IL-10, neopterin (r = .72), TNF-alpha (r = .76), IL-6 (r = .68), and IL-8 (r = .61) levels in patients with septic shock. Monocyte/macrophage activation leads to massive secretion of IL-10, which, however, seems to be unable to control the increased production of proinflammatory mediators during septic shock. |
| Databáze: | OpenAIRE |
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